In this study, we recruited families with non-syndromic oligodontia and identified two novel LRP6 mutations: a de novo frameshift mutation by a 1-bp insertion in exon 9 (c.1870dupA, p.(Met624Asnfs*29)) and a splicing donor site mutation in intron 8 (c.1762+2T>C). Here, LRP6 is linked to Oligodontia.