CYP2C19 and eosinophilic esophagitis: In children who received a dose of PPI between 1.54 and 2.05 mg/kg/day (the estimated dose to reach 80 mg per day), a binary logistic regression model showed that the presence of the CYP2C19 *17 allele was associated with a higher risk of PPI-insensitive eosinophilic esophagitis [21].