Relatedly, Gunia et al. reported the expression of p53, p21, and cyclin D1 in 11 patients with penile carcinoma with elevated levels of p53 could be used as a prognostic factor; however, in a multivariate analysis, the relationship for p21 or cyclin d1 was not strong enough for them to be used as prognostic markers [39]. This evidence concerns the gene TP53 and penile carcinoma.