Mean CRP and fibrinogen levels were significantly different between HLH and non-HLH patients (169 vs 128 mg/L and 3.5 vs. 4.8 g/L, respectively, p < 0.001), and they were especially low in patients with acute hepatitis (mean, 81 mg/L and 2.7 g/L). Here, CRP is linked to hemophagocytic syndrome.