In the univariate regression models for each SAMS factor, we again found that the number of medications per day (p < 0.001) and depression (p < 0.001) exerted the strongest influence on modification, whereas the number of medications (p < 0.001), MoCA (p < 0.001) and depression (p = 0.042) had the strongest impact on missing knowledge. Here, DOCK3 is linked to major depressive disorder.