Eryptosis is further triggered by a wide variety of xenobiotics and is enhanced in a variety of clinical disorders (i.e., iron deficiency, metabolic syndrome, diabetes, fever and dehydration, sepsis, hemolytic uremic syndrome, mycoplasma infection, myelodysplastic syndrome, phosphate depletion, malaria, sickle-cell anemia, beta-thalassemia, glucose-6-phosphate dehydrogenase-(G6PD)-deficiency, hereditary spherocytosis, paroxysmal nocturnal hemoglobinuria, and Wilson’s disease) [2,5,8,9,10,11,12]. The gene discussed is G6PD; the disease is Beta-thalassemia.