The chronic inflammation associated with obesity due to excessive intra-abdominal fat tissue (IFT) leads to increased production of adipokines (IL-6, TNFa, monocyte chemoattracting protein-1, and plasminogen activator inhibitor-1) with proinflammatory, pro-fibrogenic, pro-angiogenic, and pro-oxidant effects on most tissues [1]. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.