HPSE and acute respiratory distress syndrome: Indeed, in patients with severe ARDS, an increase in the activity of heparanase on day 1 (5.7 [5.1–6.1]) and day 3 (5.8 [4.8–6.0]) was observed when compared to patients with moderate (day 1: 5.3 [4.6–5.9], day 3: 5.2 [4.6–5.9]) and mild ARDS (day 1: 4.9 [4.6–5.4]; day 3: 5.0 [4.3–5.4]) (Figure 1).