On the contrary, some studies showed an absence of association between TLR4 SNP and sepsis; a study conducted by Kumpf et al. found no association between Asp299Gly and Thr399Ile polymorphisms of TLR4 and the incidence of sepsis syndrome or the type of organisms causing surgical infection in German adults [20]. The gene discussed is TLR4; the disease is systemic inflammatory response syndrome.