For example, steroids have been reported to reduce the number and type I IFN responses of pDCs in systemic lupus erythematosus (SLE) patients; however, it is important to note that after the discontinuation of glucocorticoids, both pDC number and IFNα levels recovered rapidly in the patients [193,194]. This evidence concerns the gene IFNA2 and systemic lupus erythematosus.