It is important to note that antibiotic therapy can easily destroy this vulnerable system, since antibiotics not only target pathogenic bacteria but also kill or drastically reduce the numbers of commensal bacteria, which are responsible for sustaining tonic levels of IFN signals, and thus antibiotics eliminate the body’s baseline antiviral state [40,41], and increase the risk of viral infections and inflammatory conditions [39]. This evidence concerns the gene IFNA1 and viral infectious disease.