In 23 people from the 659 patients with severe COVID-19 autosomal recessive (IRF7, IFNAR1) and autosomal dominant (TLR3, UNC93B1, TICAM1, TBK1, IRF7, IRF3, IFNAR1, IFNAR2) deficiencies were found. The gene discussed is IRF7; the disease is COVID-19.