A dose-finding and dose-expansion phase 1b trial conducted by Choueiri et al. [140], regarding the use of avelumab, a PD-L1 inhibitor, in association with axitinib, a tyrosine kinase inhibitor (TKi), in patients with clear-cell renal-cell carcinoma reported one case of myocarditis diagnosed before the first evaluation of the patients, resulting in the death of the patient. The gene discussed is CD274; the disease is myocarditis.