Hypodiploid B-ALL is also characterized by the elevated expression of BCL-2 and BIM and low levels of BCL-XL, and were highly sensitive to both navitoclax and venetoclax, suggesting that the balance of BCL-2/BCL-XL expression influences the sensitivity to specific BCL-2 inhibition [19]. The gene discussed is BCL2L11; the disease is acute lymphoblastic leukemia.