It is well established that various NRs such as androgen receptors (ARs), estrogen receptors (ERs), farnesoid X receptors (FXRs), peroxisome proliferator-activated receptor γ (PPARγ), retinoic acid receptors (RARs), retinoid X receptors (RXRs), and vitamin D receptor (VDR), which shows association with cancer development [28,36,59,60]. The gene discussed is RARS1; the disease is cancer.