Indeed, all activators (LPS, IL-4, WGP, and tumor supernatant) upregulated Dectin-1, but not TLR-2 and TLR-4, highlighted an enhancement of Dectin-1 on the non-specific activations of macrophages, perhaps as a preparation for the possible following activations [24,55,56,57]. This evidence concerns the gene TLR4 and neoplasm.