CGAS and cancer: Because we hypothesized that beta-glucan on the S. cerevisiae cell wall (WGP) attenuates cancers in cGAS-/- mice, the subcutaneous injection of cancer cell line (MC38) with the intralesional injection of S. cerevisiae crude extract (yeast extract), WGP, or normal saline solution (NSS) control was performed in cGAS-/- mice (Figure 3A).