Oral administration of Saccharomyces cerevisiae reduced the growth of colon cancers in cGAS-deficient (cGAS-/-) mice in the models using azoxymethane (AOM) induction and subcutaneous injection of cancer cells, possibly through energy enhancement in macrophages through whole glucan particle (WGP)-induced Dectin-1. This evidence concerns the gene CGAS and malignant colon neoplasm.