Accumulated self-dsDNA in cancer cells induce a cGAS conformational change to catalyze the formation of 2’,3’-cyclic GMP-AMP (cGAMP), a cyclic dinucleotide (CDN) from ATP and GTP that activates the stimulator of interferon genes (STING), results in the local production of type-I interferon (IFN-I)-induced cell apoptosis [17]. Here, CGAS is linked to cancer.