Moreover, it is well known that elevation of miR-185 was associated with selenium deficiency leading to MF; furthermore, pathological changes accompanied by increased miR-185 exerted a reduction of antioxidant properties such as glutathione peroxidase-1(GPx-1) levels in a cellular model of endothelial cells mimicking glycemic variability [57]. The gene discussed is GPX1; the disease is selenium deficiency.