Target molecules CYR61, TIMP1, SOD2, IL6, SERPINE2, DUSP1, TNFSF9, OSMR, TNFRSF10D, and TNFRSF12A play vital roles in regulating cell proliferation, apoptosis, cycle and migration, and they can be used as biomarkers for the treatment of PCa by the MTS derivative HXL131. This evidence concerns the gene TNFRSF12A and posterior cortical atrophy.