In comparison with the breast tissue specimens of 114 normal healthy individuals, the expression of GDF15 was significantly higher in 1097 breast cancer samples (p < 0.0001) (Figure 3C), including 784 infiltrating ductal carcinomas (IDC) (p < 0.0001), 203 infiltrating lobular carcinomas (ILC) (p < 0.0001), 29 mixed histology (p < 0.01), 17 mucinous carcinomas (p < 0.01), and 9 metaplastic carcinomas (p < 0.05) (Figure 3D). The gene discussed is GDF15; the disease is invasive ductal breast carcinoma.