HK1 and proximal spinal muscular atrophy: A comparative gene expression profiling of murine MN pools—with different SMA vulnerability—showed that phosphoglycerate kinase 1 (PGK1), a key glycolytic enzyme, is specifically down-regulated in SMA vulnerable MNs, and, when overexpressed or pharmacologically activated, can ameliorate SMA phenotype in zebrafish embryos [89].