In four-month-old APP/PS1 mice with Alzheimer’s disease (AD), it was found that URMC-099 can restore synaptic integrity and hippocampal neurogenesis via facilitating Aβ clearance in the brain [43], implying multifaceted immune modulatory and neuroprotective roles of URMC-099. This evidence concerns the gene APP and early-onset autosomal dominant Alzheimer disease.