The expression of RBMS3 downregulates the expression of TWIST1 and, consecutively, its downstream target MMP2, leading to EMT impairment [9]Loss of RBMS3 impairs the growth of the tumor and its ability to create metastasis by influencing expression and stabilizing PRRX1 mRNA, a transcription factor regulating EMT [80]. Here, PRRX1 is linked to neoplasm.