ACHE and Alzheimer disease: Reduced levels of nAChRs and cholinergic neurotransmission have been implicated in the etiology of AD, and acetylcholinesterase inhibitors are used to treat AD [10,11] Given these reports on the critical role of proteins modulating synaptic plasticity in the pathogenesis of AD, it seems reasonable to investigate their potential clinical utility and compare them with classical biomarkers.