Exosomes isolated from cancer cell lines and exosomal fractions obtained from cancer patient plasma confirm the expression of various immunosuppressive molecules, including death receptor ligands such as FasL and TNF-related apoptosis-inducing ligand (TRAIL), checkpoint receptor ligands such as PD-L1, inhibitory cytokines, such as IL-10 and TGF-β, and non-coding RNAs [194]. The gene discussed is TNFSF10; the disease is cancer.