However, in diet-induced obesity (DIO) models, some studies have indicated that UCP1 levels remained stable or, as in the work by Alcalá M. et al., UCP1 protein levels increased in obese mice after HFD intervention for 20 weeks, which was not comparable to our study of just 9 weeks, but its coherence showed an evolution [43,44]. Here, UCP1 is linked to obesity due to melanocortin 4 receptor deficiency.