To investigate the relationships of synaptic-related biomarkers (i.e., Ng, α-Syn, the Aβ 42/Ng ratio, and the Aβ 42/α-Syn ratio), non-parametric variables were log10-normalized, and then, we performed univariate linear regression analysis to investigate the influence of clinical features and AD-core biomarkers on their values (Table S4). The gene discussed is NRGN; the disease is Alzheimer disease.