As illustrated in Figure 1, we found significantly higher levels of CSF Ng (Figure 1a) and α-Syn (Figure 1b) in AD compared to n-ND patients (Ng: AD = 388 (238–531) pg/mL vs. n-ND = 242 (95–375) pg/mL, p < 0.001; α-Syn: AD = 2756 (2226–3164) pg/mL vs. n-ND = 1735 (1218–2393) pg/mL, p < 0.001), with a size effect that did not influence the final results (Ng: η2 = 0.095; α-Syn: η2 = 0.169). This evidence concerns the gene NRGN and Alzheimer disease.