CACNA1A and Generalized non-motor (absence) seizure: For example, the tottering mutation (Cacna1atg) that occurs in the Cacna1a for the CaV2.1 subunit gives rise to polyspike discharges and behavioral absence seizures [190,191,192], while the leaner mutation in the same gene leads to cortical spike-wave discharges in the animals with cerebellar atrophy [190,191,193].