TSC1 and epilepsy: Mutations in some genes such as sodium voltage-gated channel alpha subunit 1 (SCN1A), can cause epilepsies or syndromes with epilepsy as the core symptom [17], while other genes such as tuberous sclerosis complex-1&2 (TSC1 and TSC2) may be associated with gross brain developmental malformations and epilepsies [18] or neurodevelopmental disorders due to gene mutations such as Fragile X Syndrome (FMR1) [19], Tubulin β3 Class III, and WD Repeat Domain 62 (TUBB3 and WDR62) [20,21].