For example, the tottering mutation (Cacna1atg) that occurs in the Cacna1a for the CaV2.1 subunit gives rise to polyspike discharges and behavioral absence seizures [190,191,192], while the leaner mutation in the same gene leads to cortical spike-wave discharges in the animals with cerebellar atrophy [190,191,193]. The gene discussed is CACNA1A; the disease is juvenile absence epilepsy.