Chronic exposure of human neuroblastoma SH-SY5Y cells to Mn significantly decreases the expression level of the miRNAs miR-7 and miR-433, which reportedly modulate synaptic transmission and apoptosis and target SNCA (the gene that expresses α-synuclein) and FGF-20 (a growth factor) [105]. The gene discussed is SNCA; the disease is neuroblastoma.