COL1A1 and keratoconus: In a genome-wide association study, significant associations with KC have been identified within or close to genes including COL1A1 (rs2075556, p = 3.35 × 10−09), COL5A1 (rs3118518, p = 1.83 × 10−28), COL6A1 (rs142493024, p = 9.07 × 10−12), and COL12A1 (rs35523808, p = 2.90 × 10−25) [75].