JAK2 and cancer: It is known from the literature that mechanisms of biological activity of compounds containing azabicyclo[3.1.0]hexane fragments may affect tumor protein p53 (indeed, TP53 gene is the most frequently mutated gene (>50%) in human cancer) and signal cascades such as STAT3/p-STAT3-JAK2/p-JAK2 as well as the target MDM2/p53 complex [36,37].