The heatmap of the top 3 specific TFs of each cell type showed the activation status of specific regulatory factors in each cell type, among which only 10 TFs (Bhlhe22, Lhx9, Ovol2, Cux2, Uncx, Rarb, Sox9, Emx2, Tbx2, Nr1h3) were co-activated in the same cell types of PD and CN, but the regulatory intensity was different (Figure 2B). Here, EMX2 is linked to Parkinson disease.