Finally, the activation status of the other 54 TFs suggested that there was a general homogeneity in the activation or inhibition of TFs in all cell types; only Rarb and Foxp2 were simultaneous activated and inhibited in different cell types, and Maf and Xbp1 were activated or inhibited in almost all neurons of PD, respectively (Figure S4). The gene discussed is XBP1; the disease is Parkinson disease.