Our comparative study showed that all patients with chronic OD had a basal time to LVC greater than 340 ms and that stimulation with capsaicin (TRPV1) and piperine (TRPV1/A1), both at 150 μM, produced the greatest reduction in the time to LVC, below 340 ms cutoff, and to UESO. Here, TRPV1 is linked to osteochondritis dissecans.