SREBF2 and posterior cortical atrophy: It has been shown that ACAT-1, an enzyme essential for cellular cholesterol storage, and SREBP-2, a transcription factor involved in cholesterol uptake, are associated in PCa cells with the process of epithelial to mesenchymal transition (EMT), which allows cancer cells to acquire migratory and invasive characteristics, properties essential for dissemination and distant metastasis [41].