Glymphatic pathway-related aquaporin4 (AQP4) distribution changed from perivascular to parenchymal pattern [66], thus suggesting that a perturbed glymphatic pathway due to the aberrant dislocation of the AQP4 water channel along with neuroinflammation may have contributed to the development of amyloid deposits in the post-stroke state. The gene discussed is AQP4; the disease is Stroke.