All the women with breast cancer analyzed retrospectively here show a high incidence of overweight and obesity since diagnosis, this condition represents a metabolic factor that is an imbalance in the storage and expenditure of lipids, insulin resistance [19], cardiovascular changes [20], increases in circulating lipids, hormonal imbalance, and increased proinflammatory cytokines [21,22]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.