LEP and obesity due to melanocortin 4 receptor deficiency: The comparison between factors such as age, molecular type, and recurrence analyzed with respect to the L/M index, CEA, and CA 15-3 antigens shows that the values remain elevated in luminal types in patients who presented recurrence, in the same way as in the group of women >55 years old, possibly due to the effect on estrogen production due to the imbalance of the progesterone-leptin-estrogen axis, with overweight and obesity as a common factor in the population studied.