GPT and obesity due to melanocortin 4 receptor deficiency: NAFLD induction by short-term (10-week) HFD feeding in C57BL/6 mice is much milder than in the current study (e.g., mild steatosis; very early—not histologically quantifiable—inflammation; no fibrosis; ALT levels well within the normal range) and in absence of the metabolic dysfunction phenotype (obesity, insulin resistance, dyslipidemia) that characterizes most NASH patients.