NAFLD induction by short-term (10-week) HFD feeding in C57BL/6 mice is much milder than in the current study (e.g., mild steatosis; very early—not histologically quantifiable—inflammation; no fibrosis; ALT levels well within the normal range) and in absence of the metabolic dysfunction phenotype (obesity, insulin resistance, dyslipidemia) that characterizes most NASH patients. Here, GPT is linked to Insulin resistance.