Fibrosis in SSc is caused by chronically activated myofibroblasts, and constant activation of fibroblasts is enhanced by interleukin 6 (IL-6), platelet-derived growth factor (PDGF), and transforming growth factor-beta (TGF-β), released by the immune and vascular systems [4]. The gene discussed is TGFB1; the disease is systemic sclerosis.