We found that the copper(II) complex CuL5, a thiosemicarbazone–pyridylhydrazone that incorporates a benzofuran functional group, reduced secretion of pro-inflammatory cytokines MCP-1, decreased expression of Tnf, increased expression of Mt1, and modulated expression of Alzheimer’s disease-associated risk genes, Trem2 and Cd33 in murine microglia. Here, MT1A is linked to Alzheimer disease.