The molecular alterations in sepsis onset when bacteria PAMPs as lipopolysaccharide (LPS) are recognized by PRR such Toll-like receptor 2 (TLR2) or Toll-like receptor 4 (TLR4) that activate myeloid differentiation factor 88/IL-1 receptor-associated kinase 1/tumor necrosis factor receptor-associated factor 6 (MyD88/RAK/TRAF6) signaling pathways to induce activation of NFκB, and subsequently, excessive release of pro-inflammatory cytokines such interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-17 (IL-17), and TNFα generated hyperinflammation. The gene discussed is IL6; the disease is Sepsis.