CTBP2 and cancer: Mechanistically, it is proved that tumor-resident MDSCs increase cancer cell stemness through the upregulation of microRNA101, which targets the co-repressor gene C-terminal binding protein-2 (CtBP2) 3′-UTR region and interferes with its binding at NANOG, OCT4/3, and SOX2 promoters in primary OC cells [65].