The chemokines CXCL10 and CCL4 are found elevated in MAs, with CXCL10 being associated with increased anti-tumor response in a mouse central nervous system model [208] and the intratumoral expression of CCL4 correlated with the inhibition of colorectal tumor growth and tumor-specific CD8+ T cells response [209]. The gene discussed is CCL4; the disease is colorectal neoplasm.