NFKB1 and neoplasm: Yin et al., [77] showed that TAMs were localized within spheroid centers and secreted EGF, by the signaling pathway EGF–EGFR [78], causing an upregulation of integrins and VEGF signaling by the activation of the NF-κB and JNK signaling pathways [79], supporting both tumor cell proliferation and migration.