Alternatively activated macrophages, or M2-like, are polarized by anti-inflammatory stimuli such as IL-4, IL-10, and IL-13 and they release IL-6, IL-10, IL-13, TGF-β, VEGF-A, arginase, normally related with wound healing, cellular proliferation, the resolution of inflammation, immunosuppression, tumor invasion, tumor growth, angiogenesis, and metastasis [29,72]. The gene discussed is IL4; the disease is neoplasm.