VEGFA and neoplasm: In addition, tumor cells can impair DC maturation and recruit immunosuppressive cells (myeloid-derived suppressor cells [MDSCs] and regulatory T-cells [Tregs]) by maintaining interleukin (IL)-6, IL-10, and vascular endothelial growth factor (VEGF)-A levels in the TME, consequently attenuating the T-cell response against tumors [12,13,14].