CTLA4 and neoplasm: As shown in Figure 5C–E, both regimens, i.e., anti-CTLA-4 antibody combined with regorafenib plus chidamide-k30 and anti-CTLA-4 antibody combined with cabozantinib plus chidamide-k30, were more potent in inhibiting tumor growth than the positive controls anti-CTLA-4 antibody combined with CC-02 and anti-CTLA-4 antibody alone.