The CXCR4/CXCL12 axis seems to play an important role in the desmoplastic reaction characterizing PDAC [16], while CXCR3/CXCL10 resulted expressed in pancreatic tumor tissue [35], and their presence has been correlated with poor prognosis [36]. The gene discussed is CXCR3; the disease is pancreatic neoplasm.