The LSL-KrasG12D/+; Pdx1Cre/+ mouse model, referred to hereafter as KC, developed the entire compendium of precursor ductal lesions with a slight proportion developing invasive, metastatic adenocarcinoma after a long latency (>1 year) [30], whereas LSL-KrasG12D/+; LSL-p53R172H/+; Pdx-1-Cre (named KPC) was the more aggressive mouse model. Here, PDX1 is linked to keratoconus.