Tumor cells undergo metabolic reprogramming through several regulatory pathways such as HIF-1α, PI3K/Akt or c-myc, resulting in an overexpression of the glucose transporters (GLUT1, GLUT2 and GLUT4) found expressed in PDAC [52,53], as well as in the upregulation of several glycolytic genes [54]. Here, HIF1A is linked to neoplasm.