For example, miR-125b expression is upregulated in cardiac hypertrophy and HF, and miR-125b in human cancers promotes the proliferation and survival of tumor cells through repression of BCL2 antagonist/killer 1 (BAK1), p14ARF (ARF-tumor-suppressor protein), suppression of tumorigenicity 18 (ST18), and tumor protein p53 (TP53). The gene discussed is TP53; the disease is cardiac hypertrophy.