It should be noted that this is the first study to reveal that apolipoproteins—specifically, Apo-A1, Apo-A2, Apo-C1, and Apo-D—might constitute valuable biomarkers of metabolic imbalance, which could be used for the long-term prognosis of the development of overweight and obesity among ALL survivors. This evidence concerns the gene APOA2 and obesity due to melanocortin 4 receptor deficiency.