The correlation found between the concentration of IL-6 measured <4.5 h and 1 day after the onset of worsening of stroke symptoms (NIHSS scale), both on admission and discharge from the hospital, and TNF-α, and the NIHSS scale on admission proves that these cytokines can be considered a potential marker of the extent of ischemic brain injury and its further clinical consequences [45]. This evidence concerns the gene TNF and brain injury.