In addition to the previous works on the roles of ASICs, TRPV1, and P2X receptors [70], we will focus on the updated research of ASIC3 and the interaction effect of ASIC3 and P2X3 on muscle sensory nerves in mediating the exaggerated sympathetic response in hindlimb muscle ischemia seen in PAD patients. Here, TRPV1 is linked to peripheral arterial disease.