ASIC3 and peripheral arterial disease: Prior to utilizing the genetic approach of ASIC3 knockout, several studies were performed to assess the role played by ASIC3 in evoking the exercise pressor reflex in PAD by comparing with sham control rats on the protein expression currents [82] of ASIC3 in DRG [81], and the blood pressure responses before and after the application of pharmacological blockades (e.g., amiloride and APETx2) [100].