Meanwhile, the role of nerve growth factor (NGF) in regulating the metabolic receptors in the ischemia-muscles of PAD has been extensively discussed in one of the previous reviews [104], highlighting its elevation under the ischemia condition and upregulating the protein expression and function of ASIC3, P2X3, and TRPV1 in the DRG neurons. Here, P2RX3 is linked to peripheral arterial disease.