Meanwhile, the role of nerve growth factor (NGF) in regulating the metabolic receptors in the ischemia-muscles of PAD has been extensively discussed in one of the previous reviews [104], highlighting its elevation under the ischemia condition and upregulating the protein expression and function of ASIC3, P2X3, and TRPV1 in the DRG neurons. The gene discussed is NGF; the disease is peripheral arterial disease.