To determine whether SPIN90 interacts genetically with Aβ deposition, 5xFAD mice, a model of AD characterized by the rapid accumulation of Aβ plaques due to the expression of APP mutant transgenes [25,26], were mated with SPIN90 KO mice, which have been used in functional studies of membrane trafficking and neural function [24,27]. Here, APP is linked to Alzheimer disease.