In AD, CD36 forms a complex with TLR4 and TLR6 that is responsible for the secretion of the proinflammatory cytokine, including IL-6, TNF-α, NO, and chemokines [194] (Figure 2), which activates inflammatory signaling in the astrocytes through the PI3K/Akt signaling pathway [192]. The gene discussed is AKT1; the disease is Alzheimer disease.