IL-1β blocking with IL-1β antibodies alleviated memory and cognitive dysfunction in 3xTg-AD mice by suppressing NF-κB activation and reduced tau phosphorylation by decreasing the activation of tau-related kinases cdk5/p25, GSK-3β, and p38-mitogen-activated protein kinase (p38 MAPK) [118]. Here, MAPT is linked to Alzheimer disease.