Hence, the presence of the homozygote genotype with the T allele will lead to a lower level of MMP-2 and, consequently, a protective effect against the negative aspect of gelatinase A. On this basis, it is assumed that people with the CC genotype may show an increased susceptibility to the incidence of type 2 diabetes by overexpression of the MMP-2 protein [29]. Here, MMP2 is linked to type 2 diabetes mellitus.