TIMP1 and type 2 diabetes mellitus: There was no significant correlation between T2D and TIMP-1 (A/G), while +279 A/G (rs17576) and COL4A3 (G/T) were positively correlated with type 2 diabetes, with COL4A3 (G/T) as a protective factor and +279 A/G (rs17576) as risk factor (Table 2) [39,40].