However, in the oral fluids of patients with type 2 diabetes, increased levels of miR-146a have been observed, which may lead to the up-regulation of angiotensin converting enzyme 2 (ACE2) expression; these are essential SARS-CoV-2 receptors, and modulate the host anti-viral response in these patients [142]. The gene discussed is ACE2; the disease is type 2 diabetes mellitus.