Due to the fact that important targets for miR-223 involved in infection and inflammation are TNF receptor-associated factor 6 (TRAF6), forkhead box O1 (FOXO1), TLR4, STMN1, PI3K/AKT, C-X-C motif chemokine ligand 2 (CXCL2), CCL3, IL-6, IFN-I, IL-1β, Caspase-1 (and, mainly, NLRP3), inhibitor of nuclear factor kappa-B kinase subunit alpha (IKKα), and NF-κB, it participates in regulating the inflammatory process while also indicating antioxidant and anti-viral roles, suggesting miR-223 as a potential regulatory factor in the process of COVID-19 immunopathogenesis [108]. The gene discussed is AKT1; the disease is COVID-19.