Based on bioinformatic analyses, it has been indicated that miR-155 may be associated with some genes involved in the immune response, apoptosis, and COVID-19 progression, such as STAT1, STAT3, transforming growth factor beta 1 (TGFB1), mothers against decapentaplegic homolog 3 (SMAD3), IRF1, AKT1, MYB proto-oncogene (MYB), BCL6, TP6, hypoxia inducible factor 1 subunit alpha (HIF1A), forkhead box P3 (FOXP3), AP-1 transcription factor subunit (JUNB), and nuclear factor kappa B subunit 1 (NFKB1) [71]. The gene discussed is SMAD3; the disease is COVID-19.