Therefore, we attribute the increase in Ca2+ deposits in SaOS-2 cultures in the presence of 1 mM TEA to KCa1.1 inhibition, as it was shown in MG-63 osteoblast-like osteosarcoma cells [12,13,32], primary osteoblasts [13] and bone-marrow-derived human mesenchymal stem cells during osteogenic differentiation [14]. This evidence concerns the gene KCNMA1 and osteosarcoma.